Tauroursodeoxycholic acid
CAS Number: 14605-22-2 Tauroursodeoxycholic acid (TUDCA), chemically known as 3α,7β-dihydroxycholanoyl-N-taurine, is a conjugated bile acid formed by the dehydration condensation between the carboxyl group of ursodeoxycholic acid (UDCA) and the amino group of taurine.
Keywords:
Bile acids, prednisolone derivatives, and epiandrosterone derivatives
Category:
Tauroursodeoxycholic acid (TUDCA), chemically known as 3α,7β-dihydroxycholanoyl-N-taurine, is a conjugated bile acid formed by the dehydration condensation between the carboxyl group of ursodeoxycholic acid (UDCA) and the amino group of taurine. TUDCA was first isolated from bear bile in 1902 and is the major bile acid in bear bile, exhibiting spasmolytic, anticonvulsant, anti-inflammatory, and cholelitholytic activities. Tauroursodeoxycholic acid (tauroursodeoxycholic acid, 1) is the active constituent of bear bile; its chemical name is 2-[[((3α,5β,7β)-3,7-dihydroxy-24-oxocholest-24-en-24-yl]amino]ethanesulfonic acid dihydrate. It was developed by the Italian pharmaceutical company Beside and was first launched in Italy in 1991. In 2007, it was approved for sale in China under the trade name Taurolite and is primarily used in clinical practice for the treatment of cholesterol gallstones, primary sclerosing cholangitis, primary biliary cirrhosis, and chronic hepatitis C. Clinical studies have shown that, compared with ursodeoxycholic acid, compound 1 accelerates stone dissolution, increases the complete dissolution rate, and is associated with no significant adverse reactions.
| Basic Information | |
| Chinese name: | Tauroursodeoxycholic acid |
| Chinese alias: | Tauroursodeoxycholic acid |
| English name: | Sodium tauroursodeoxycholate |
| Specifications | greater than or equal to 98% or greater than or equal to 99% |
| Chemical properties | |
| Molecular formula: | C26H45NO6S.2H2O |
| Molecular weight: | 499.70 |
| Purity: | greater than or equal to 98% or greater than or equal to 99% |
| MDL Number: | MFCD00069496 |
| Melting point | 173–175 degree C |
| Quality Standards | |
| Appearance | White or milky-white powder |
| Identification (infrared) | Consistent with the reference standard |
| Content (HPLC) | greater than or equal to 98% or greater than or equal to 99% |
| pH （ 1%，H2O ) | 6.5–9.0 |
| Loss on drying | less than or equal to 8% |
| Heavy metals | less than or equal to 20ppm |
| Clarity and color of the solution ( 1%，H2O ) | Colorless to pale yellow, clear and transparent solution |
| Nature of the hazard | |
| RTECS Number KI7372500 | |
| WGK Germany 2 | |
| Storage | |
| Store in a sealed, dry place. | |
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